Elucidating the behavior of an enzyme

Rated 4.36/5 based on 803 customer reviews

First, we identify that the pupal stage is selectively sensitive to Me Hg toxicity.Using a protocol of larval feeding, measurements of Hg body burden, and assays of development to adulthood (pupal eclosion), we identify strain-dependent variation in Me Hg elimination as a potential kinetic determinant of differential tolerance to Me Hg.(A) Drosophila development from embryo to adult is holometabolous and progresses through intermediate larval and pupal stages.

Methylmercury (Me Hg) is an environmental toxicant and contaminant of seafood that arises from both natural and anthropogenic sources.The risks of Me Hg exposure are greatest during early life, and it has long been understood that the developing nervous system is an especially sensitive target.However, a number of studies have demonstrated a wide variation in neurological outcomes associated with prenatal and early life Me Hg exposure, ranging from none at all to measurable motor and cognitive deficits that can be persistent in children through adolescence (Grandjean et al., 1997; Murata et al., 2004; Davidson et al., 2006; Davidson et al., 2008).GSH can act directly as a conjugate with Me Hg to mediate transport, distribution, and excretion (Ballatori and Clarkson, 1982; Ballatori and Clarkson, 1983).GSH also acts as a first line of defense to oxidative stressors and can moderate toxicity stemming from a Me Hg insult dynamically by buffering ROS (Shanker et al., 2005; Kaur et al., 2006).

Leave a Reply